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Termini Station is a key railway junction for the city and for the whole country: about 800 trains leave here each day for every Italian city. Thanks to the High Speed Service, for example, Milan can be reached in about 3 hours!
There are also several secondary stations situated in various parts of the city (Tiburtina, Ostiense, Trastevere, Tuscolana).
For more information: www.trenitalia.it